The Fountain of Youth has been an unobtainable fantasy for thousands of years, but with advancements in modern science, we might be closer than ever to turning this legend into reality. Backed by billions in funding the longevity market is on the rise and expected to reach $271 billion by 2024.
These companies can roughly be grouped into two types: The first consists of companies that focus on slowing down the aging process to increase the lifespan of humans while second consists of companies that use AI and advanced algorithms to prevent death altogether.
Here are some of the most innovative longevity biotechs in the world:
CEO - Seth Ettenberg
Located in Massachusetts, BlueRock is an industry leader in creating induced pluripotent stem cells (iPSC) used in neurology, cardiology, and immunology. BlueRock has developed a one-of-a-kind cell+gene that reprograms mature cells back to iPSC’s and enhances their therapeutic capabilities. Advanced bioprocess techniques are then used to re-differentiate these iPSCs, which can replace damaged or diseased cells.
COO - Ann Lee-Karlon
Located in California, Altos Bio is working on technology that can reprogram cells to rejuvenate and potentially prolong human life. This technology works using materials that can cause cells to revert to an earlier embryonic stage, effectively reversing the aging process.
CEO - Alex Zhavoronkov
Located in Hong Kong, Insilico Medicine uses AI and deep learning technology for drug discovery and drug repurposing for age-related diseases. This allows for the identification of molecules that can be used to treat various cancers and other central nervous system diseases.
CEO - Anirvan Ghosh
Located in California, Unity Biotechnology develops transformative medicines to halt, prevent or reverse aging-induced diseases. Unity Biotechnology creates medications that remove the senescent cells while leaving the other cells unaffected. Senescent cells have been hypothesized to disrupt tissue structure and function, so removing these cells could prevent or delay tissue dysfunction, extending one's life span.
CEO - Joe Sarret
Located in California, CohBar Inc is developing mitochondria-based therapeutics (MBTs) to treat several age-related and metabolic dysfunction diseases like nonalcoholic steatohepatitis (NASH), obesity, fibrotic diseases, cancer and acute respiratory distress syndrome (ARDS).
CEO - Dr Nafees Malik
Located in California, AgeX Therapeutics develops medications using its PureStem and induced Tissue Regeneration (iTR) technology to address some of the unsolved issues in aging. AGEX-VASC1, AGEX-BAT1, and AGEX-iTR1547 are three PureStem derived cell-based therapy candidates in development.
CSO - Mourad Topors
Located in New York, Repair Biotechnologies develops gene and protein therapies to reverse age-related thymic atrophy and the loss of immunological function that follows, allowing people to live longer by addressing the causes of age-related diseases and aging itself.
CEO - Robert Hariri
Located in New Jersey, Cellularity develops off-the-shelf placental-derived allogeneic cell therapies, such as genetically modified and unmodified NK cells, engineered T cells for cancer, immunologic, infectious, and degenerative diseases.
Lineage Cell Therapeutics
CEO - Brian Culley
Located in California, Lineage Cell Therapeutics is focused on the research and marketing of innovative treatments for degenerative diseases. Cell replacement and cell/drug delivery are two platform technologies used in the company's pipeline.
CEO - Drew Taylor
Located in Canada, Acorn Biolabs provides cell preservation services for non-invasive cell freezing that can be used for future medical applications. Consumers will have access to regenerative medicine, genetics, and powerful stem cell therapy in the future thanks to the company's services.
CSO - Grazia Piizzi
Located in Ireland, Juvenescence develops therapies specializing in aging disorders and increasing human longevity. The company's therapies promote healthy lifestyles, allowing patients to slow or reverse aging.
CEO - Cynthia Colllins
Located in California, Human Longevity uses its platform that combines genetic and phenotypic data to better understand human health. The platform can address age-related decline in endogenous stem cell function and focuses on shifting medicine for diseases like cancer, diabetes, dementia, and obesity from reactive to proactive technologies.
CEO & Co-founder - Mark Allen
Located in Massachusetts, Elevian develops regenerative medicine aimed at preventing and treating age-related disorders by identifying blood factors that regulate aging and stimulating the body's natural repair and regeneration mechanisms.
CEO - Jerry McLaughlin
Located in Massachusetts, Life Biosciences develops drugs specializing in promoting longevity and developing remedies for age-related disorders. The company's drugs are intended to counteract the eight pathways of age-related decline.
Calico Life Sciences
CMO - Aarif Khakoo
Located in California, Calico Life Sciences develops technologies intended to better understand the biology that governs one’s lifespan. The company's services are focused on the health and well-being of persons suffering from aging-related diseases, with the goal of reducing their effects and allowing people to live long and healthy lives.
CEO - Cevdet Samikoglu
Located in California, BioSplice Therapeutics is a tissue-level therapeutic medication company that aims to heal degenerative patients by identifying new targets and biological processes in the Wnt pathway, allowing them to create small molecule medications intended to treat a variety of degenerative diseases and cancers.
CEO - Matthew Scholz
Located in Washington, Oisin Biotechnologies develops senolytic therapies intended to reduce the consequences of aging. The company's technique employs an unique proteo-lipid vehicle drug delivery platform to induce apoptosis in a senescent cell without hurting nearby healthy cells, allowing clinicians to tackle age-related disorders.
CEO & Co-founder - Michael Hufford
Located in Pennsylvania, LyGenesis develops cell treatment technology for organ regeneration and transplantation. The technology focuses on liver regeneration for patients with end-stage liver disease, allowing surgeons to rebuild functional organs within a patient's own body using lymph nodes.
CEO & Founder - Doug Ethell
Located in California, Leucadia Therapeutics has developed a medical technology platform aimed at providing unique and enhanced Alzheimer's disease treatments.
CEO - Louis Hawthorne
Located in California, NaNotics has developed a nano platform to treat solid tumor malignancies and autoimmune illnesses. The platform uses nano-extractors that remove specific circulating molecular signals or signal inhibitors that drive or enable disease progression. This allows doctors to provide patients with a safe treatment option.
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