Exploring the Human Microbiome: Unveiling the Top 20 Companies Leading Microbiome Research in the US

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Exploring the Human Microbiome: Unveiling the Top 20 Companies Leading Microbiome Research in the US

The Importance of Microbiome Research

Microbiome research is of immense importance as it provides crucial insights into the complex ecosystem of microorganisms living within and on our bodies. The microbiome plays a vital role in human health, affecting various aspects such as digestion, immune function, and metabolism. By studying the microbiome, scientists can gain a deeper understanding of its impact on diseases like obesity, diabetes, and autoimmune disorders, potentially leading to new diagnostic and treatment strategies. Furthermore, microbiome research is essential for developing personalized medicine approaches, as individual variations in the microbiome can influence how individuals respond to drugs and therapies. Ultimately, unlocking the mysteries of the microbiome holds tremendous potential for advancing human health and well-being.

Painting a Picture of the Human Microbiome Market

The human microbiome market is expected to grow at a CAGR of 24% and reach USD 1,800 million by 2027. The human microbiome consists of a vast population of bacteria, viruses, and other microbes. that play an important role in our bodily functions. Today, we are able to obtain a deeper understanding of the microbiome and develop new microbe-based treatments and technologies to cure illnesses of all kinds. 

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The Top Microbiome Companies that are Leading the Charge

Here are the top 20 innovative microbiome companies in the US:

Axial Biotherapeutics

Located in Waltham, Massachusetts, Axial Biotherapeutics is a clinical-stage company that develops biotherapeutics intended to treat neurological disorders. Using their proprietary drug development platform and expertise in the gut-brain axis, Axial Biotherapeutics aims to transform the treatment of Central Nervous System(CNS) diseases.


Located in Chicago, Illinois, BiomeSense has created a bioinformatics platform and integrated biosensors to track, analyze and store microbiome profiles. This enables continuous collection and analysis of gut microbiome data during clinical trials.


Located in Birmingham, Alabama, ResBiotic develops probiotic therapies that restore the human lung microbiome. They specialize in developing an anti-inflammatory probiotic product that can reduce neutrophilic inflammation, which helps cure patients of their respiratory illness faster. 

Finch Therapeutics

Finch Therapeutics is a biotechnology company based in Somerville, Massachusetts, that is focused on developing microbiome-based therapies for a variety of diseases. The company's approach involves using human-derived microbiota to create drug products that can target specific diseases by restoring a healthy microbiome. Finch has a particular focus on gastrointestinal diseases, including inflammatory bowel disease, as well as other conditions such as autism spectrum disorder and allergies. The company has received significant funding and has several ongoing clinical trials for its microbiome-based therapies.


Located in Bellevue, Washington, Viome creates a digital representation of the human body and its microbiomes on a molecular level and provides health insights on nutritional information based on at-home tests. These tests are analyzed using RNA sequencing technology and artificial intelligence (AI). 

Second Genome

Located in South San Francisco, California, Second Genome uses its proprietary biotechnology platform to identify novel proteins and peptides within the microbiome. The data they glean from their platform will enable researchers to develop new precision therapies.

Persephone Biosciences

Located in San Diego, California, Persephone Biosciences develops precision medicines focused on the microbiome for immuno-oncology purposes. They identify microbes required for normal immune function using AI and synthetic biology on the gut microbiome of cancer patients.

Sun Genomics

Located in San Diego, California, Sun Genomics creates custom probiotics based on a person's gut DNA to treat dysbiosis. The company uses genome sequencing to help customers realize the power of microbiome through genomics, probiotics, and software.


Located in Wilmington, Delaware, Microgenesis offers a non-invasive test that can detect an imbalance of the vaginal and intestinal microbiome which can lead to inflammation in women struggling to conceive. Microgenesis offers tools and advice to treat this imbalance and help women tackle infertility.


Located in Oakland, California, AnimalBiome develops microbiome diagnostics and therapeutics for pets to identify biome imbalances and create custom supplements to improve gut health.

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BrickBuilt Therapeutics

Located in Allston, Massachusetts BrickBuilt Therapeutics develops treatments for oral health. The company uses Live Biotherapeutic Products (LBPs) to eliminate pathogens and rebuild a healthy microbial community.


Located in Roseville, Minnesota, Rebiotix develops drugs using human microbes to treat gastrointestinal diseases. The company's novel approach to treating diseases is delivering microbes into a sick patient's intestinal tract. 


Located in San Francisco, California, Oralta produces a probiotic supplement for bad breath. This supplement is made from a blend of highly effective strains that eliminate odor-causing bad bacteria and restore a healthy equilibrium of beneficial bacteria.

Evelo Biosciences

Located in Cambridge, Massachusetts, Evelo Biosciences is a clinical-stage company that develops orally delivered medicines designed to act on cells in the small intestines and provide therapeutic effects. Currently, the company has four products in development — EDP1908 for the treatment of cancer and EDP1815, EDP1867, and EDP2939 for the treatment of inflammatory diseases.

Siolta Therapeutics

Located in San Francisco, California, Siolta Therapeutics develops therapeutics using the human microbiome to treat inflammatory disease.


Located in Danville, CA, Nexilico is an early-stage company developing next-generation precision medicine to advance microbiome R&D using computational technologies to understand microbiome-related drug metabolism.

Seres Therapeutics

Located in Cambridge, Massachusetts, Seres Therapeutics is a clinical-stage company that develops Ecobiotic™ therapeutics designed to treat dysbiosis in the colonic microbiome. The company's product SER-109 is used to prevent Clostridium difficile infection (CDI).

Scioto Biosciences

Located in Indianapolis, Indiana, Scioto Biosciences is a preclinical stage company that uses its proprietary Activated Bacterial Therapeutics (ABT) platform to deliver live therapeutic bacteria to the gut to advance healing for diseases associated with oncology and the GI tract.


Located in Branford, Connecticut, Azitra is a preclinical stage company that develops novel microbiome-based therapies to treat skin conditions and diseases like ichthyosis vulgaris, eczema, inflammatory skin, and many more.

Vedanta Biosciences

Located in Cambridge, Massachusetts, Vedanta Biosciences develops novel therapies that modulate interaction pathways between the human microbiome and the immune system. These therapies are designed from a consortium of human commensal bacteria using information from human interventional studies.

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Lab Management Software for Microbiome Companies: Scispot.io

Scispot has become the primary lab management software of choice for numerous modern biotech companies, including microbiome companies. Digitize your biotech startup for free.

Scispot creates a connected digital replica of these innovative bioscience companies. It centralizes their company-wide data, templatizes routine research and automates non-scientific tasks. It makes other lab software such as electronic lab notebooks (ELNs) and lab information management systems (LIMS) redundant.

Microbiome Companies use Scispot's operating platform to manage their research projects, inventory, samples, and partners all in one spot. Request a demo to learn how you can accelerate your research using Scispot.

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