HT Screening

Automate the data work between your screen and the next experiment.

Build your screening lab’s Digital Brain with Scispot. Automate plate-data intake, run configured assay checks, and prepare hit-review evidence while scientists decide which results are ready for the next experiment.
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Explore LabOS

Trusted by 200+ life science labs

Supporting 250+ instrument types, more than 1,000 experiments each month, and millions of samples across diagnostics, genomics, biotech, and regulated testing.

Your best fit

Built for screening teams whose instruments outpace their data handoffs.

Connect biochemical and cell-based screens from compound transfers through assay plates, readouts, and follow-up decisions. Start where file handling and QC preparation cost scientists the most time.

Map your screening workflow
Features

Published Customer Outcomes

From plate data to reviewed follow-up work.

50%

Less data-processing time

Organoid-screening customer; imaging and sequencing processing: six days to three.

15% → 5%

Lower data-entry error rate

Reduced data-entry errors in one connected biotech workflow.

Up to 50%

Less manual reporting and admin

Cut manual reporting and administration work for one biotech.

40%

Less time creating cross-team requests

Peptide teams reduce time creating cross-team requests.

One system, three layers

A Digital Brain from plate data to the next reviewed action.

Prepare plates from assay plans

Record assay versions, compounds or perturbations, concentrations, controls, replicates, and source-to-destination wells. Prepare worklists from the plan and flag missing assignments before handoff.

Scientists compare planned and recorded transfers. Shared plate identities keep bench teams, automation leads, and analysts on the same map as preparation changes.

Import readouts and run checks

GLUE maps supported reader files to plate and well records using agreed identifiers and units. Preserve original files and flag incomplete imports for review.

Smart Actions runs configured calculations and QC checks. Preview outputs before saving; retain controls, settings, and exclusions so scientists can assess suitability for hit review.

Prepare evidence for hit confirmation

Bring primary results, repeats, concentration-response outputs, and orthogonal evidence into candidate review. Surface missing confirmation work and prepare follow-up queues from recorded decisions.

Scientists select, defer, or reject compounds. Retain the assay, method, and supporting evidence with each decision, keeping primary hits distinct from confirmed results.

One connected operating layer

More plates should not mean more spreadsheet work.

Scispot carries plate data through configured checks, scientific review, and follow-up preparation so increasing screening output creates less manual reconciliation.

Ask which screening results
are ready for the next experiment.

Find the evidence and prepare the next handoff.

Meet Scibot
Scibot, the Scispot AI coworker
Which plates failed our QC rules?
Trace this hit to its source well
Compare control drift across this screen
Find missing results for plate HTS-204
Show compounds awaiting confirmatory testing
Draft a handoff from reviewed hit decisions
Which plates failed our QC rules?
Trace this hit to its source well
Compare control drift across this screen
Find missing results for plate HTS-204
Show compounds awaiting confirmatory testing
Draft a handoff from reviewed hit decisions
AI-native lab transformation

Less data handling from plate setup through scientific review.

Plate Work Without Re-entry

Carry compound IDs, concentrations, controls, and well relationships into transfers and results. Flag mismatches before the next worklist or screen review.

Instrument Data That Arrives Ready

GLUE imports supported liquid-handler and plate-reader files into agreed records. Automate identifier mapping and completeness checks while retaining sources and unresolved exceptions.

Configured Assay Analysis

Smart Actions runs agreed normalization, QC, or response calculations. Review outputs before committing updates; retain inputs, settings, and exclusions for scientific assessment.

Screening Workflows With Expert Delivery

Jazz gives operators and reviewers focused screens on shared Scispot data. Our scientists and engineers map assays, connect files, test calculations, and train teams.

Automate the digital work around your screening decisions.

01

Primary Screening to Hit Review

Prepare plate evidence without rebuilding separate exports.

Import transfer and reader files against the compound map and assay layout. Run configured checks for missing wells, units, and controls, keeping source data beside calculated outputs.

Route flagged plates to review. Scientists assess plate quality and document which results can enter hit selection; the next team receives the decision with its supporting records.

Explore primary screening workflows

02

Concentration-Response Confirmation

Review dilution series and fit evidence together.

Match compounds, concentrations, repeat plates, and raw measurements. Run configured response calculations or import existing analysis outputs, retaining methods, units, exclusions, and their reasons.

Prepare IC50 or EC50 results where appropriate, with fit quality and observations. Scientists review inconclusive results and decide whether further work is needed before advancement.

Explore hit confirmation workflows

03

Assay Transfer and Optimization

Compare assay versions before changing the next campaign.

Compare plate results across cell preparations, reagent lots, incubation, and readout settings using each plate’s recorded method version.

Our scientists and engineers test data flows and review steps with your team. Record chosen conditions and open questions, carry approved setups forward, and retain earlier versions.

Explore assay transfer workflows

Start with your most time-consuming screening handoff.

Bring an assay protocol, plate map, and reader export. Our scientists and engineers will scope and test useful automation, measuring data handling or hit-review readiness.
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FAIR data • pipelines • automation

Instruments • ELN/LIMS/SDMS • 200+ connectors

FAIR data • pipelines • automation

Instruments • ELN/LIMS/SDMS • 200+ connectors

Frequently asked questions

What does high throughput screening software manage?

High throughput screening software manages assay plans, plate and well identities, instrument data, QC, and follow-up work. Scispot captures supported files, runs configured checks and calculations, and prepares review queues. Your scientists define assay criteria and decide which results support hit selection or confirmation.

Can Scispot connect our liquid handlers and plate readers?

Scispot connects supported interfaces and files. Our scientists and engineers review worklists, exports, software versions, and identifiers, then test source-to-destination well mapping, returned values, incomplete files, and exceptions with your team. Any commands sent to equipment require a separately confirmed interface and workflow scope.

Can we keep our screening database and analysis tools?

Keep your compound registry, ELN, screening database, and specialist analysis tools. Agree identifier ownership and data exchange, then test one plate-to-review workflow with representative records and train its users. Measure manual handling and adoption before extending it to another assay.

Does Scispot calculate Z′ and dose-response results?

Configure Smart Actions or connect analysis outputs for your assay: Z′ for suitable control-based plate assessment, or IC50 and EC50 for relevant concentration-response work. Test inputs, units, settings, and exclusions with your scientists. Review proposed outputs before committing updates; scientific acceptance remains a separate decision.

How does Scispot support a controlled screening workflow?

Scispot provides permissions, record history, source links, review steps, and electronic signatures where configured. Trust Vault supports controlled evidence. For regulated use, Quality defines procedures, validation scope, and approvals. Scientists retain responsibility for assay suitability and candidate decisions; software controls support their review and data integrity.

Keep screening evidence controlled and decisions reviewable.

Scispot supports controlled records, source traceability, permissions, and review workflows. Your team owns assay suitability, acceptance criteria, scientific decisions, required validation, and final sign-off.